Myrcene 1.37% and ß-Caryophyllene 0.46% are the dominant terpenes with Limonene 0.13% and Guaiol 0.11% also present in significant amounts. Further discussion follows.
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Myrcene a known anti-inflammatory via prostaglandin E2 blockade. This mechanism as well via modulation of the α-2 adrenoreceptor seams to lead to its analgesic effects. In relatively high doses its hypnotic effect may be as effective as diazepa in sleep duration. Additionally, myrcene can lead to muscle relaxation. On top of all of this, it has also been shown to block metabolism of Xenobiotics through the CYP2B1 enzyme, effectively preventing mutagenicity of genotoxic substances in liver cells.
ß-Caryophyllene is a Powerful Anti-inflammatory via Prostaglandin E-1 inhibition on par with indomethacin (a last resort NSAID) but instead of causing ulcers has been found to be gastroprotective! ß-Caryophyllene is also one of the only other substances found to also bind and activate the CB2 receptor therefore augmenting the action of CBD. Sleep latency and muscle relaxation are
Limonene is anti-inflammatory and may and may help prevent cancer with its antiproliferative, apoptosis-inducing and chemopreventive effects. The results of a 2010 study suggest that limonene may have potential anti-inflammatory efficacy for the treatment of bronchial asthma by inhibiting cytokines, ROS production, and inactivating eosinophil migration and therefore potentially useful in treating asthma. In a 2012 study limonene was found to have anxiolytic effects, and it could serve as a new approach for the treatment anxiety, since it practically does not produce toxic effects.